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T-Cell (T-Lymphocyte)
is any
lymphocyte that matures in the thymus.
Teratogen
is a substance that produces a malformation in a foetus. This is
distinct from mutagenicity, which causes genetic mutations in sperms,
eggs or other cells. Teratogenicity is a potential side effect of
many drugs, such as thalidomide.
Three-dimensional
Quantitative Structure-Activity Relationship (3D-QSAR)
is the analysis of the quantitative relationship between
the biological activity of a set of compounds and their spatial
properties using statistical methods.
Thrombocytopenia:
low number of platelets in the blood.
Thymus is
a lymphoid organ in the chest that is the site of lymphocyte
formation and maturation as well as the secretion of thymic hormones.
An important function of the thymus is to weed out lymphocytes that
react to proteins produced by the body (.self-antigens.), thus preventing
autoimmune disease. The thymus is a large organ during childhood,
but shrinks with adolescence.
Topliss tree
is an operational scheme for analog design.
Transition-state
analog is a compound that mimics the transition state of
a substrate bound to an enzyme.
Triple-Blind
Study is a study in which knowledge of the treatment is
concealed from the people who organize and analyze the data of a
study as well as from subjects and investigators.
Van der Waals
forces are the sum of the attractive intermolecular forces
that vary with the power of six of their distance and include dispersion
forces, permanent dipole-dipole forces, and permanent dipole-induced
dipole forces.
Virus: disease-causing
parasites much smaller than bacteria. A virus is a noncellular entity
composed merely of genetic material (DNA or RNA) surrounded by a
protein envelope. Viruses can reproduce only within living cells
into which they inject their genetic material. The viral genes then
subvert an infected cell.s normal chemical processes to create new
virus particles, usually killing the cell in the process.
Viral Load: the
number of viral particles in a sample of blood plasma.
Vmax
is a kinetic parameter. The rate of an enzyme catalyzed reaction
tends to a limiting value termed Vmax, at saturating concentrations
of substrate. 0.5 Vmax is termed the reaction Km, or Michaelis constant,
or apparent dissociation constant.
Volume of Distribution
relates the amount of drug in the body to the concentration of drug
in blood or plasma.
Warning Letter
A written communication in letterform from the Food and Drug Administration-U.S.Govt.
The purpose is to advise a person, or corporation that the FDA considers
one or more products, practices, processes, or other activities
to be in violation of the Federal FD&C Act, or other acts. Further,
the letter states that failure of the responsible party to take
appropriate and prompt action to correct and prevent any future
violations may result in enforcement action.
Washout Period
in the clinical study is the time during which subjects receive
no treatment for the indication under study and the effects of a
previous treatment are eliminated (or assumed to be eliminated).
Western Blot
is a procedure where proteins are electrophoresed and transferred
to nitrocellulose and then probed with a specific antibody or other
probe molecule.
Xenobiotic is
a compound foreign to an organism (xenos [greek] = foreign).
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