Medicinal Chemistry Encyclopedia

 

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T-Cell (T-Lymphocyte) is any lymphocyte that matures in the thymus.

 

Teratogen is a substance that produces a malformation in a foetus. This is distinct from mutagenicity, which causes genetic mutations in sperms, eggs or other cells. Teratogenicity is a potential side effect of many drugs, such as thalidomide.

 

Three-dimensional Quantitative Structure-Activity Relationship (3D-QSAR) is the analysis of the quantitative relationship between the biological activity of a set of compounds and their spatial properties using statistical methods.

 

Thrombocytopenia: low number of platelets in the blood.

 

Thymus is a lymphoid organ in the chest that is the site of lymphocyte formation and maturation as well as the secretion of thymic hormones. An important function of the thymus is to weed out lymphocytes that react to proteins produced by the body (.self-antigens.), thus preventing autoimmune disease. The thymus is a large organ during childhood, but shrinks with adolescence.

 

Topliss tree is an operational scheme for analog design.

 

Transition-state analog is a compound that mimics the transition state of a substrate bound to an enzyme.

 

Triple-Blind Study is a study in which knowledge of the treatment is concealed from the people who organize and analyze the data of a study as well as from subjects and investigators.

 

Van der Waals forces are the sum of the attractive intermolecular forces that vary with the power of six of their distance and include dispersion forces, permanent dipole-dipole forces, and permanent dipole-induced dipole forces.

 

Virus: disease-causing parasites much smaller than bacteria. A virus is a noncellular entity composed merely of genetic material (DNA or RNA) surrounded by a protein envelope. Viruses can reproduce only within living cells into which they inject their genetic material. The viral genes then subvert an infected cell.s normal chemical processes to create new virus particles, usually killing the cell in the process.

 

Viral Load: the number of viral particles in a sample of blood plasma.

 

Vmax is a kinetic parameter. The rate of an enzyme catalyzed reaction tends to a limiting value termed Vmax, at saturating concentrations of substrate. 0.5 Vmax is termed the reaction Km, or Michaelis constant, or apparent dissociation constant.

 

Volume of Distribution relates the amount of drug in the body to the concentration of drug in blood or plasma.

 

Warning Letter A written communication in letterform from the Food and Drug Administration-U.S.Govt. The purpose is to advise a person, or corporation that the FDA considers one or more products, practices, processes, or other activities to be in violation of the Federal FD&C Act, or other acts. Further, the letter states that failure of the responsible party to take appropriate and prompt action to correct and prevent any future violations may result in enforcement action.

 

Washout Period in the clinical study is the time during which subjects receive no treatment for the indication under study and the effects of a previous treatment are eliminated (or assumed to be eliminated).

 

Western Blot is a procedure where proteins are electrophoresed and transferred to nitrocellulose and then probed with a specific antibody or other probe molecule.

 

Xenobiotic is a compound foreign to an organism (xenos [greek] = foreign).