SARvision|Biologics 4.6.02

SARvision|Biologics 4.6.02 is released to study Sequence Activity Relationships for your peptides, proteins and nucleotide biologics. It has a number of enhancements focused on alignment, the Dendrogram View, the Logoplot View and the Scatterplot View.

1.       The Dendrogram View has been completely revamped to allow the users to build based on any numeric properties in the data table in addition to sequence identity.

2.       Heatmapping has been added to the Dendrogram View to color the dendrogram based on any numeric data in the data table.

3.       Mouse overs have been added to the Dendrogram View to display average value of the children nodes for the heatmap by property data and the cluster by property values.

4.       The Dendrogram View is now build on demand by the user with a Rebuild button in the control.

5.       The Scatter Plot View now has a better selection of default coloring (red, blue, yellow, green….).

6.       The Scatter Plot View zoom sliders can now be adjusted by typing in a specific value into the control in addition to using the sliders.

7.       The Logo/Bar Plot View now has option to the following apply transformations to the y-axis: (linear, log(y), log2(y), ln(y) and inverse (1/y)).

8.        The Logo/Bar Plot View has added functionality to rotate and display bars and or letters.

9.       The ability to align to an existing alignment has been rebuilt to better reflect alignment modified by the user (add / remove gaps). It slower but the results are better. This is used when data is reloaded or new data is imported into an existing project.

10.   Additional parameters used for the alignment are now loaded and saved with the project so that become defaults for new alignment and for aligning sequences to existing.

11.   The function in expressions, CountRings(), has been modified to better count macrocyclic rings. It now counts the number of ring closures using a single sidechain crosslink.

12.   Mouse fly over for residue structures are now oriented N->C by default for alpha amino acid building blocks.

13.   Because many macrocyclic peptides are hard to draw from smiles, the user can now add a framework scaffold (scaffolds.sdf) to the resource folder. This is a list of molecule backbones that can be used to orient and clean the structures derived from mouse overs of a smiles column in the data table the entire molecules.

14.   Key board short cuts for ctrl-S, ctrl-O and ctrl-N have been added.

15.   Right-click copy can select entire rectangular selections in the data table.

16.   A number of changes have been made to improve stability of the program.